HepCnet Logo, Hepatitis C information and support, hep c information, hepatitis c message boards chat support and informationHepatitis C resources and support hepcnet, abigsam and lyric hepatitis c information and support Make a Donation »  
 
Main Page | About HepCnet | Contact Info
Hepatitis C
F.A.Q.
Viral Hepatitis C - Frequently Asked Questions
Nutrition & Hep C
Nutrition and Diet Recommendations for people with Chronic Hepatitis C
Nutrition & Cirrhosis
Nutrition information for people with Cirrhosis
Drugs & Liver Damage
Drugs that may cause liver dysfunction or damage
Hepatitis C Tests
Serologic Tests Used to Diagnose Hepatitis C
Scoring/Staging Hepatitis C & Cirrhosis
Scoring Systems for Staging of Chronic Hepatitis and Cirrhosis
Message Boards
Open Discussion
Treatments & Studies
Heppo Friends & Fun
HepCnet Chat
aBigSam and Lyric's
Hep C Support Chat
Member Stories
Read members stories about how Hepatitis C has affected their lives

Photo Album

Pictures of some of our members
Artistic Expressions
Various forms of art submitted by our members
News & Info
Heppo Fest information and other News
Heppo
Recipe Exchange
Recipes submitted by HepCnet members
Sign Guestbook
View Guestbook
Make an entry to our Guestbook and let us know that you were here!
Related Links
Other sites that offer information and support about Hepatitis C
Link to Us!
How to Link your Web Site to HepCnet
Web Rings & Awards
Web rings that HepCnet has joined and awards received
The Hep C Stuff Archive
The official repository for every member of HepCnet to store info and links
Top    Back

Scoring and Staging Hepatitis C
Scoring Systems for Staging of Chronic Hepatitis
Various scoring systems are used to evaluate the amount of fibrosis in chronic hepatitis.
Score Description Knodel Sciot and Desmet (unpublished) Scheuer
0 No fibrosis No fibrosis None None
1 Mild fibrosis Fibrous portal expansion Periportal fibrous expansion Enlarged,fibrotic portal tracts
2 Moderate fibrosis   Porto-portal septa
(> 1 septum)
Periportal or portal-portal septa, but intact architecture
3 Severe fibrosis Bridging fibrosis
(portal-portal or portal-central linkage)
Portocentral septa
(> 1 septum)
Fibrosis with architectural distortion, but no obvious cirrhosis
4 Cirrhosis Cirrhosis Cirrhosis Probable or definite cirrhosis

From: Desmet: Hepatology:(1994) 19:1513; Knodell: Hepatology:(1981) 1:431; Scheuer: J Hepatology:(1991) 13:372

HAI (histological activity index) by Knodell

    I. Periportal +/- Bridging Necrosis [Score]
      A. none [ 0]
      B. mild piecemeal necrosis [1]

      C. moderate piecemeal necrosis (involve less than 50% of the circumference of most portal tracts) [3]

      D. marked piecemeal necrosis (involve more athan 50% of the circumference of most portal tracts) [4]

      E. moderate piecemeal necrosis plus bridging necrosis plus bridging necrosis [5]

      F. marked piecemeal necrosis plus bridging necrosis plus bridging necrosis [6]

      G. multilobular necrosis [10]
    II. Intralobular Degeneration and Focal Necrosis
      A. none [0]
      B. mild (acidoplhilic bodies, balooning degeneration and/or scattered foci of hepatocellular necrosis in < 1/3 of lobules or nodules) [1]

      C. moderate (involvement of 1/3 ~ 2/3 of lobules or nodules) [3]

      D. marked (involvement of > 2/3 of lobules or nodules) [4]
    III. Portal Inflammation
      A. no portal inflammation [0]
      B. mild (sprinkling of inflammatory cells in < 1/3 of portal tracts) [1]

      C. moderate (increased inflammatory cells in 1/3 ~ 2/3 of portal tracts) [3]

      D. marked (dense packing of inflammatory cells in > 2/3 of portal tracts) [4]
    IV. Fibrosis
      A. no fibrosis [0]
      B. fibrous portal expansion [1]

      C. bridging fibrosis (portal-portal or portal-central linkage) [3]

      D. cirrhosis [4]

From Knodell RG et al.; Formulation and application of a numerical scoring system for assessing histological activity in asymtomatic chronic active hepatitis. Hepatology, (1981) 1:431


Grading system for cirrhosis: the Child-Pugh score
Score Bilirubin
(mg/dl)
Albumin
(gm/dl)
PT (Sec) Hepatic
encephal
Ascites
(grade)
1 < 2 > 3.5 1 - 4 None None
2 2 - 3 2.8 - 3.5 4 - 6 1 - 2 Mild
3 > 3 < 2.8 > 6 3 - 4 Severe

Child class: A= 5 - 6, B= 7 - 9, C= > 9

 

 

    Page last updated: March 7, 2003


Home  |  About HepCnet  |  Contact Information
Hep C FAQ  |  Nutrition & Hep C |  Nutrition & Cirrhosis
Drugs & Liver Damage  |  Hep C Tests  | Scoring/Staging Hepatitis C & Cirrhosis
HepCnet Message Boards  |  HepCnet Chat  |  Artistic Expressions  |  Member Stories  
Photo Album  |  News & Info  |  Heppo Recipe Exchange  |  Sign Guestbook  |  View Guestbook
The Hep C Stuff Archives  |  Related Links  |  Web Rings & Awards  |  Link to HepCnet!

Copyright 2000, 2001, 2002. 2003 HepCnet.net. All rights reserved

Site Design by Wolf Web Publications.